Ethical approval must be obtained before medical research can start. We describe the differences in EA for an pseudonymous, non-interventional, observational European study. Sixteen European national coordinators of the international study on very old intensive care patients answered an online questionnaire concerning their experience getting EA. N = 8/16 of the NCs could apply at one single national ethical committee, while the others had to apply to various regional ECs and/or individual hospital institutional research boards. The time between applying for (...) EA and the first decision varied between 7 days and 300 days. In 9/16 informed consent from the patient was not deemed necessary; in 7/16 informed consent was required from the patient or relatives. The upload of coded data to a central database required additional information in 14/16. In 4/16 the NCs had to ask separate approval to keep a subject identification code list to de-pseudonymize the patients if questions would occur. Only 2/16 of the NCs agreed that informed consent was necessary for this observational study. Overall, 6/16 of the NCs were satisfied with the entire process and 8/16 were unsatisfied. 11/16 would welcome a European central EC that would judge observational studies for all European countries. Variations in the process and prolonged time needed to get EA for observational studies hampers inclusion of patients in some European countries. This might have a negative influence on the external validity. Further harmonization of ethical approval process across Europe is welcomed for low-risk observational studies. Getting ethical approval for low-risk, non-interventional, observational studies varies enormously across European countries. (shrink)

Following the Introduction, the essays to be listed, each with a reply by Errol E. Harris, comprise the principal content. B. Blanshard, “Harris on Internal Relations”; G.R. Lucas, Jr., “Science and Teleological Explanations”; J.E. Smith, “Harris’ Commentary on Hegel’s Logic”; G. Rinaldi, “The Identity of Thought and Being in Harris’ Interpretation of Hegel’s Logic”: T. Rockmore, “System and History: Harris on Hegel’s Logic”; R. Hepburn, “The Problem of Evil”; W. H. Walsh, “Hegel on Morality”; W.N.A. Klever, “The Properties of the (...) Intellect”; P. Muller, “The pons asinorum in Philosophy”; Wm. Earle, “The Evanescent Authority of Philosophy.”. (shrink)

Following the Introduction, the essays to be listed, each with a reply by Errol E. Harris, comprise the principal content. B. Blanshard, “Harris on Internal Relations”; G.R. Lucas, Jr., “Science and Teleological Explanations”; J.E. Smith, “Harris’ Commentary on Hegel’s Logic”; G. Rinaldi, “The Identity of Thought and Being in Harris’ Interpretation of Hegel’s Logic”: T. Rockmore, “System and History: Harris on Hegel’s Logic”; R. Hepburn, “The Problem of Evil”; W. H. Walsh, “Hegel on Morality”; W.N.A. Klever, “The Properties of the (...) Intellect”; P. Muller, “The pons asinorum in Philosophy”; Wm. Earle, “The Evanescent Authority of Philosophy.”. (shrink)

Following the Introduction, the essays to be listed, each with a reply by Errol E. Harris, comprise the principal content. B. Blanshard, “Harris on Internal Relations”; G.R. Lucas, Jr., “Science and Teleological Explanations”; J.E. Smith, “Harris’ Commentary on Hegel’s Logic”; G. Rinaldi, “The Identity of Thought and Being in Harris’ Interpretation of Hegel’s Logic”: T. Rockmore, “System and History: Harris on Hegel’s Logic”; R. Hepburn, “The Problem of Evil”; W. H. Walsh, “Hegel on Morality”; W.N.A. Klever, “The Properties of the (...) Intellect”; P. Muller, “The pons asinorum in Philosophy”; Wm. Earle, “The Evanescent Authority of Philosophy.”. (shrink)

Combinatie van vertaling en uitleg van de 'Ethica', het hoofdwerk van de Nederlandse filosoof (1632-1677).

Vertaling (verkorte versie) van en commentaar op de wijsgerige verhandeling van de Nederlandse filosoof (1632-1677) over de betekenis van het christendom.

Linear chromosomes shorten in every round of replication. In Drosophila, telomere‐specialized long interspersed retrotransposable elements (LINEs) belonging to the jockey clade offset this shortening by forming head‐to‐tail arrays at Drosophila telomere ends. As such, these telomeric LINEs have been considered adaptive symbionts of the genome, protecting it from premature decay, particularly as Drosophila lacks a conventional telomerase holoenzyme. However, as reviewed here, recent work reveals a high degree of variation and turnover in the telomere‐specialized LINE lineages across Drosophila. There appears (...) to be no absolute requirement for LINE activity to maintain telomeres in flies, hence the suggestion that the telomere‐specialized LINEs may instead be neutral or in conflict with the host, rather than adaptive. (shrink)

Business Ethics, the Environment & Responsibility, Volume 31, Issue 2, Page 589-600, April 2022.

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be (...) preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)